Abstract:

The Salience Network has not been a focus in schizophrenia research to the same extent other pathways have. It has been suggested to have a role in cognition, self-awareness, communication and social interaction, all processes disrupted in schizophrenia.

Here we briefly review the evidence for pathological change in the main structures of the Salience Network; the insular cortex, anterior cingulate cortex, substantia nigra, ventral striatum, amygdala and mediodorsal thalamus in schizophrenia to examine whether there is evidence for widespread disruption in this circuit to justify further consideration in ongoing research.

Keywords:

SALIENCE, INSULA, CINGULATE, PATHOLOGY, SCHIZOPHRENIA