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Mania With Depressive Symptoms: A Pathophysio-Logical Review

Key messages

● Bipolar disorder (BD) is a common, complex, and costly psychiatric illness that can be devastating for the

affected individual and their families. Suicide is an important risk across the life span of bipolar patients.

● Accurate diagnosis is not easy, particularly in mixed states. Psychotic symptoms may suggest schizophrenia,

and a major depressive episode may appear to be unipolar depression. Comorbid anxiety and substance/

alcohol abuse often…

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