The ANGELS Initiative, in collaboration with the European Stroke Organisation (ESO) and supported by Boehringer Ingelheim, was launched in 2016 in Europe, with the original aim of establishing 1,500 European stroke-ready hospitals and improving the standard of acute stroke care and patients’ outcomes in Europe by May 2019. In the subsequent three years since launch, the ANGELS programme has expanded its sphere of influence significantly, and internationally; it now engages with stroke physicians, nurses, and emergency medical services (EMS) in more than 2,700 hospitals in 95countries.